IBI-363 is a PD-1/IL-2 bispecific antibody with functions of blocking the PD-1/PD-L1 pathway and activating the IL-2 pathway. The IL-2 arm of IBI-363 retains affinity for IL-2Ralpha but attenuates binding ability to IL-2Rbeta and IL-2Rgamma to reduce toxicity. The PD-1 binding arm of IBI-363 enables PD-1 blockade and selective delivery of IL-2. IBI-363 can be used in cancer research, such as non-small cell lung cancer[1].
Molecular Weight:
(112.48 kDa)
Purity:
99.60
Target:
Interleukin Related,PD-1/PD-L1
Application Notes:
MCE Product type: Inhibitory Antibodies
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