Anti-Mouse CD80 Antibody (TKMG48) Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-P992062
Supplier Catalog Number:
HY-P992062
Alternative Catalog Number:
MCE-HY-P992062-1UNIT
Manufacturer:
MedchemExpress
Category:
Antikörper
Anti-Mouse CD80 Antibody (TKMG48) is an antibody that targets mouse CD80. By specifically binding to and disrupting the CD80:PD-L1 complex to release PD-L1, Anti-Mouse CD80 Antibody (TKMG48) functions as an indirect PD-1 agonist without blocking CD28 co-stimulation or CD80-CTLA4 binding. Anti-Mouse CD80 Antibody (TKMG48) inhibits T cell activation, reduces T cell effector functions and antigen-specific CD8+ T cell populations, and does not interfere with the differentiation, migration, antigen presentation or surface marker expression of dendritic cells. Anti-Mouse CD80 Antibody (TKMG48) significantly attenuates disease severity in mouse models of arthritis, spondyloarthritis, multiple sclerosis and Sjögrens syndrome, and its activity depends on the expression of PD-1 and PD-L1[1][2].
Target:
PD-1/PD-L1
Application Notes:
MCE Product type: Inhibitory Antibodies
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