Anti-Mouse DDR2 Antibody (DAB0065) Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-P992066
Supplier Catalog Number:
HY-P992066
Alternative Catalog Number:
MCE-HY-P992066-1UNIT
Manufacturer:
MedchemExpress
Category:
Antikörper
Anti-Mouse DDR2 Antibody (DAB0065) is a mAb that specifically targets mouse discoidin domain receptor DDR2 without cross-reacting with DDR1. Anti-Mouse DDR2 Antibody (DAB0065) binds to the extracellular domain of native mouse DDR2, induces endocytosis and lysosomal degradation of DDR2, and this process is independent of collagen binding. Anti-Mouse DDR2 Antibody (DAB0065) exhibits significant therapeutic effects in both the unilateral ureteral obstruction (UUO) mouse model of renal fibrosis and the bleomycin (HY-108345)-induced mouse model of pulmonary fibrosis, effectively downregulating the mRNA expression of type I collagen Col1a1 and fibronectin Fn1. Anti-Mouse DDR2 Antibody (DAB0065) can be humanized and has the potential to be developed as a targeted agent for diseases such as idiopathic pulmonary fibrosis and renal fibrosis[1][2].
Target:
Discoidin Domain Receptor
Application Notes:
MCE Product type: Inhibitory Antibodies
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