Anti-ZnT8 Antibody (mAb43) is a monoclonal antibody targeting the zinc transporter ZnT8, with islet-specific biodistribution characteristics. Anti-ZnT8 Antibody (mAb43) binds to extracellular ZnT8 on the surface of pancreatic beta-cells and masks its insulin-co-localizing sites to block autoimmune recognition. Anti-ZnT8 Antibody (mAb43) also promotes an increase in the proportion of regulatory T cells and inhibits B cell antigen presentation, thereby effectively blocking the T cell-mediated cascade of beta-cell destruction. Anti-ZnT8 Antibody (mAb43) eliminates insulitis, preserves beta-cell mass and induces seroconversion of autoantibodies, without directly altering the insulin secretion function or content of beta-cells. Anti-ZnT8 Antibody (mAb43) can be used for research related to type 1 diabetes[1].
Target:
SLC39 (Zinc Transporter)
Application Notes:
MCE Product type: Inhibitory Antibodies
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