Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1kappa monoclonal antibody. By binding to CD40L, Ruplizumab blocks its interaction with the CD40 receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2].
Molecular Weight:
(145.68 kDa)
Purity:
99.84
CAS Number:
[220651-94-5]
Target:
TNF Receptor
Application Notes:
MCE Product type: Inhibitory Antibodies
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