Flotetuzumab (MGD006, S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML)[1][2].
Molecular Weight:
(58.77 kDa)
Purity:
98.71
CAS Number:
[1664355-28-5]
Target:
CD3
Application Notes:
MCE Product type: Inhibitory Antibodies
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