Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPalpha N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity[1].
Molecular Weight:
(76.43 kDa)
Purity:
99.57
CAS Number:
[2131089-46-6]
Target:
CD47
Application Notes:
MCE Product type: Inhibitory Antibodies
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