ZINC110492 is a selective ligand of CS-deltaEx4 (a splicing isoform of citrate synthase (CS)). ZINC110492 does not bind to CS full-length (CS-FL). ZINC110492 inhibits colorectal cancer (CRC) cell growth in cells overexpressing CS-deltaEx4 with an IC50 of 7.840 µM. ZINC110492 significantly decreases both citrate and 2-hydroxyglutarate (2-HG) levels in the CS-deltaEx4-overexpressing SW1116 cells[1].
Molecular Weight:
344.32
Purity:
90
CAS Number:
[100264-64-0]
Formula:
C20H12N2O4
Target:
Biochemical Assay Reagents
Application Notes:
MCE Product type: Reference compound
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