3-CPs (3-Carbethoxypsoralen, 3-Ethoxycarbonylpsoralen) is a monofunctional furanocoumarin and a photoprotective agent targeting Staphylococcus aureus DNA, possessesing anti-UVB lethal activity. 3-CPs competitively intercalates into DNA, forming exclusively 4,5-furan-side mono-adducts upon UVB irradiation, and irreversibly inhibits the formation of cyclobutane pyrimidine dimers. 3-CPs prevents UVB-induced DNA damage by preferentially binding to strong (AT)n sites within the DNA, without inducing lethal interstrand DNA cross-links, the limited number of mono-adducts it induces can be efficiently repaired by bacteria. 3-CPs holds potential for use in the development of photoprotective formulations for skin diseases, as well as in studies investigating bacterial DNA photodamage repair mechanisms and the optimization of photochemotherapy safety[1].
Molecular Weight:
258.23
Purity:
98.36
CAS Number:
[20073-24-9]
Formula:
C14H10O5
Target:
Bacterial
Application Notes:
MCE Product type: Reference compound
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