Nitracrine (hydrochloride), CAS [[6514-85-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-U00279B
Supplier Catalog Number:
HY-U00279B
Alternative Catalog Number:
MCE-HY-U00279B-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect[1].
Molecular Weight:
360.84
CAS Number:
[6514-85-8]
Formula:
C18H21ClN4O2
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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