TS-021 is a selective, orally active, reversible and long-acting DPP-IV inhibitor, and exhibits significant inhibition selectivity against DPP-8 (> 600 fold), DPP-9 (> 1200 fold) and other peptidases (> 15,000 fold). TS-021 inhibits DPP-IV activity in human plasma with an IC50 value of 5.34 nM. TS-021 has long-term persistent plasma drug concentration and potent antihyperglycemic activity, and increases in the active form of GLP-1[1][2].
Molecular Weight:
401.45
CAS Number:
[667865-69-2]
Formula:
C17H24FN3O5S
Target:
Dipeptidyl Peptidase
Application Notes:
MCE Product type: Reference compound
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