Tigemonam is an orally active monobactam antibiotic with a Ki of 0.86 µM against Enterobacter cloacae P99 beta-lactamase and 50.8 µM against Escherichia coli TEM-1 beta-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam resists hydrolysis by multiple beta-lactamase enzymes, reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection, and thigh muscle infection[1][2][3][4][5][6].
Molecular Weight:
437.41
CAS Number:
[102507-71-1]
Formula:
C12H15N5O9S2
Target:
Antibiotic,Bacterial,Beta-lactamase
Application Notes:
MCE Product type: Reference compound
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