O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity[1][2].
Molecular Weight:
241.25
CAS Number:
[19916-73-5]
Formula:
C12H11N5O
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference Standards
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