Bropirimine (U-54461, U-54461S, PNU-54461) is an orally active TLR7 agonist. Bropirimine inhibits RANKL-induced osteoclast differentiation of mouse bone marrow-derived macrophages (BMMs). Bropirimine exhibits dose-dependent direct inhibitory effects on colony formation of cultured KK-47 and 724 cells. Bropirimine can be used for the study of cancers and bone metabolic disorders such as osteoporosis[1][2][3].
Molecular Weight:
266.10
Purity:
99.94
CAS Number:
[56741-95-8]
Formula:
C10H8BrN3O
Target:
Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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