1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC50=50-58 µg/mL), with low toxicity to normal cells[1][2].
Molecular Weight:
330.51
Purity:
99.89
CAS Number:
[542-44-9]
Formula:
C19H38O4
Target:
Akt,Apoptosis,Caspase,IAP,P-glycoprotein,PI3K
Application Notes:
MCE Product type: Natural Products
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