4-Hydroxyestrone (4-OHE1)-13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease[1][2][3].
Molecular Weight:
292.32
Formula:
C12 13C6H22O3
Target:
Endogenous Metabolite,Estrogen Receptor/ERR,Ferroptosis,Isotope-Labeled Compounds,MDM-2/p53,PDI,Reactive Oxygen Species (ROS),Sirtuin
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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