AC-45594 is a UPR activator. AC-45594 induces endoplasmic reticulum stress, activates the unfolded protein response (UPR), and drives the transition from adaptive stress signaling to terminal stress signaling, ultimately leading to cell Apoptosis. AC-45594 activates Caspase-3, induces PARP cleavage, and increases the protein level of DR5. AC-45594 selectively inhibits the growth of Ewing sarcoma cells[1].
Molecular Weight:
194.27
Purity:
99.94
CAS Number:
[18979-55-0]
Formula:
C12H18O2
Target:
Apoptosis,Caspase,PARP
Application Notes:
MCE Product type: Reference compound
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