6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 µM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells[1][2][3][4].
Molecular Weight:
137.14
CAS Number:
[329-89-5]
Formula:
C6H7N3O
Target:
NADPH Oxidase
Application Notes:
MCE Product type: Reference Standards
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