2,5-Di-tert-butylhydroquinone (BHQ) (Compound 2), an indirect food additive, is a Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor with an IC50 of 400 nM. 2,5-Di-tert-butylhydroquinone disrupts the gating function of the residue Glu309 which prevents Ca2+ from reaching their binding site. 2,5-Di-tert-butylhydroquinone regulates the activity of 5-lipoxygenase and COX-2 (IC50: 1.8 and 14.1 µM for 5-LO and COX-2, respectively)[1][2].
Molecular Weight:
222.33
Purity:
99.90
CAS Number:
[88-58-4]
Formula:
C14H22O2
Target:
Calcium Channel,COX,Lipoxygenase
Application Notes:
MCE Product type: Reference compound
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