D-Histidine (hydrochloride hydrate), CAS [[328526-86-9]]
Biozol Catalog Number:
MCE-HY-W012572A
Supplier Catalog Number:
HY-W012572A
Alternative Catalog Number:
MCE-HY-W012572A-1G,MCE-HY-W012572A-500MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu2+)[1][2][3].
Molecular Weight:
209.63
Purity:
99.46
CAS Number:
[328526-86-9]
Formula:
C6H12ClN3O3
Target:
Bacterial,Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound
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