9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis[1].
Molecular Weight:
208.21
Purity:
99.95
CAS Number:
[84-11-7]
Formula:
C14H8O2
Target:
Claudin
Application Notes:
MCE Product type: Reference compound
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