BML-278 is a SIRT1 activator (EC150: 1 µM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts[1][2].
Molecular Weight:
391.46
Purity:
98.49
CAS Number:
[120533-76-8]
Formula:
C24H25NO4
Target:
Histone Methyltransferase,Sirtuin
Application Notes:
MCE Product type: Reference compound
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