Neopterin is an immune system activator metabolized by GTP and can be produced by activated macrophages. Neopterin has the potential to resist vascular inflammation and atherosclerosis. Neopterin inhibits the phosphorylation of NF-kappaB and promotes the expression of PPAR-gamma, thereby suppressing the inflammatory response of vascular endothelial cells, reducing the formation of macrophage foam cells, and regulating the migration and proliferation of vascular smooth muscle cells. Neopterin can be used in research fields such as cardiovascular diseases (such as atherosclerosis), inflammation-related diseases and tumor immunomonitoring[1][2][3][4][5].
Molecular Weight:
253.21
Purity:
99.90
CAS Number:
[2009-64-5]
Formula:
C9H11N5O4
Target:
ERK,NF-kappaB,PPAR,Raf,Src
Application Notes:
MCE Product type: Natural Products
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