Methylchloroisothiazolinone is a widely used fungicide and also an aquatic pollutant with pro-inflammatory activity and neurotoxicity. Methylchloroisothiazolinone induces the production of pro-inflammatory cytokines (such as IL-1beta, TNF-alpha, IL-6) by activating the NF-kappaB signaling pathway and upregulating TLR4 expression, thereby triggering allergic contact dermatitis. Methylchloroisothiazolinone reduces cholinesterase activity and exacerbates oxidative stress by impairing catalase activity and disrupting redox balance. Methylchloroisothiazolinone poses significant harm to Mediterranean mussels, reducing the viability of hemocytes and digestive gland cells, inhibiting immune phagocytic function, and disrupting osmoregulatory capacity. Methylchloroisothiazolinone is used in studies on allergic contact dermatitis and related immunotoxicity mechanisms[1][2].
Molecular Weight:
149.60
Purity:
97
CAS Number:
[26172-55-4]
Formula:
C4H4ClNOS
Target:
Bacterial,NF-kappaB,Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound1
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