RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNalpha/beta receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon[1]. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity[2].
Molecular Weight:
373.21
Purity:
99
CAS Number:
[691868-88-9]
Formula:
C14H5F6N5O
Target:
HBV,HCV,IFNAR,JAK,STAT
Application Notes:
MCE Product type: Reference compound
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