CYP2E1-IN-1 (Compound 10) is an orally active cytochrome P450 2E1 (CYP2E1) inhibitor with a Kd of 7.02 µM, an IC50 of 1.64 µM, and a Ki of 0.897 µM. CYP2E1-IN-1 activates the Nrf2/HO-1 signaling pathway and inhibits ROS production, thereby alleviating pancreatic injury. CYP2E1-IN-1 has significant anti-inflammatory and antioxidant activities and can effectively reduce inflammation and oxidative stress in severe acute pancreatitis (SAP). CYP2E1-IN-1 can be used in the study of SAP and other inflammatory-related diseases[1].
Molecular Weight:
141.19
Purity:
99.95
CAS Number:
[38205-55-9]
Formula:
C6H7NOS
Target:
Cytochrome P450,Heme Oxygenase (HO),Keap1-Nrf2,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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