4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to ''staple two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.
Molecular Weight:
500.58
Purity:
97.76
CAS Number:
[124243-00-1]
Formula:
C25H24O7S2
Target:
Biochemical Assay Reagents
Application Notes:
MCE Product type: Reference compound
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