CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a Ki of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer[1][2][3].
Molecular Weight:
180.21
Purity:
99.91
CAS Number:
[14949-00-9]
Formula:
C2H4N4O2S2
Target:
Carbonic Anhydrase
Application Notes:
MCE Product type: Reference compound
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