ZIF-8 (2-Methylimidazole zinc salt) is a pyroptosis inducer that activates the caspase-1/gasdermin D-dependent pyroptosis pathway. ZIF-8 induces pyroptotic cell death accompanied by necrosis and immunogenic cell death. ZIF-8 initiates in situ immunity, activates anti-tumor immunity, and reprograms the immunosuppressive tumor microenvironment to inhibit tumor growth. ZIF-8 acts as a pH-responsive and stimulus-responsive drug release inducer. ZIF-8 is applicable to cancer-related research[1][2].
Molecular Weight:
227.59
CAS Number:
[59061-53-9]
Formula:
C8H10N4Zn
Target:
Caspase,MOFs,Pyroptosis
Application Notes:
MCE Product type: Reference compound
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