N-Methylthalidomide is a cereblon ligand derivative that acts as an E3 ubiquitin ligase ligand for the synthesis of PROTAC LLC0424N (HY-185557). LLC0424N serves as a negative control for NSD2 PROTAC degrader LLC0424 (HY-161574), with weak ability to induce NSD2 degradation and low growth inhibitory effect on cancer cells carrying NSD2 mutations[1].
Molecular Weight:
272.26
Purity:
98
CAS Number:
[42472-93-5]
Formula:
C14H12N2O4
Target:
Ligands for E3 Ligase
Application Notes:
MCE Product type: Reference compound
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