EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERalpha, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol[1].
Molecular Weight:
270.37
Purity:
98.14
CAS Number:
[2191110-79-7]
Formula:
C17H22N2O
Target:
Estrogen Receptor/ERR,Hippo (MST),Molecular Glues
Application Notes:
MCE Product type: Reference compound1
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