BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGFbetaR1 inhibitor (IC50=1.6 nM). BMS-986260 displays exquisite selectivity for TGFbetaR1 over its isozyme TGFbetaR2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGFbeta mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC50 of 350 nM and 190 nM, respectively[1].
Molecular Weight:
382.78
Purity:
99.95
CAS Number:
[2001559-19-7]
Formula:
C18H12ClFN6O
Target:
TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound
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