Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimers Abeta channel[1][2][3].
Molecular Weight:
391.42
Purity:
99.91
CAS Number:
[252049-16-4]
Formula:
C22H21N3O4
Target:
Amino Acid Derivatives,Amyloid-beta
Application Notes:
MCE Product type: Peptides
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