5-(E)-VPG Phosphoramidite (5(E)-VP-2-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent used to synthesize biologically stable oligonucleotides. 5-(E)-VPG Phosphoramidite (POM) carries a VP protecting group and can be coupled to the target oligonucleotide at the 5 end via solid-phase synthesis. The modified oligonucleotide is then constructed through oxidation and deprotection steps. 5-(E)-VPG Phosphoramidite is suitable for RNAi and viral replication research[1].
