SB-405483 is a CRBN orthosteric ligand bindign enhancer. SB-405483 potentiates degradation of CRBN substrates including CK1alpha, Wee1, IKZF1/3. SB-405483 stabilizes CRBN and reduces CRBN autoubiquitination. SB-405483 can be used for the research of cancer, such as multiple myeloma and acute myeloid leukemia[1].
Molecular Weight:
360.37
Formula:
C20H16N4O3
Target:
Casein Kinase,IKZF Family,Wee1
Application Notes:
MCE Product type: Reference compound
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