Azure C acts as a tau oligomer modulator and Abeta42 oligomerization inhibitor. It regulates hsp70 ATPase activity, thereby mediating the clearance of tau protein. Azure C reduces the levels of toxic tau oligomers by promoting the formation of non-toxic tau aggregates, rescues neuroblastoma cells from tau oligomer-induced toxicity, and binds to and inhibits Abeta42 oligomerization without suppressing its fibrillization. Azure C is generated via sequential oxidation of methylene blue or Azure B through a horseradish peroxidase-mediated reaction, and accumulates in HRP reaction media. Azure C can be used in studies related to tauopathies, including Alzheimers disease[1][2].
Molecular Weight:
277.78
Purity:
40
CAS Number:
[531-57-7]
Formula:
C13H12ClN3S
Target:
Amyloid-beta,Tau Protein
Application Notes:
MCE Product type: Reference compound
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