Z57346765 is an inhibitor that targets the ADP-binding pocket of PGK1, with a Kd of 20.9 µM for human PGK1, and exhibits anticancer activity. Z57346765 reduces the activity of the metabolic enzyme PGK1 during glycolysis, regulates lipid peroxidation and cancer cell proliferation, and promotes lipid peroxidation in cervical cancer cells. Z57346765 inhibits the proliferation of cervical cancer and clear cell renal cell carcinoma cells in xenograft mouse models, and induces the expression of genes associated with cell metabolism, DNA replication and cell cycle. Z57346765 is used in research related to cervical cancer, clear cell renal cell carcinoma and breast cancer[1][2][3].
Molecular Weight:
294.36
Purity:
99.59
CAS Number:
[1016340-64-9]
Formula:
C17H18N4O
Target:
Phosphoglycerate Kinase (PGK)
Application Notes:
MCE Product type: Reference compound
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