MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 µM). MAO-B-IN-46 (Compound 8) also acts as an alpha-amylase inhibitor (IC50: 19.46 µM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 µM and 17.71 µM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinsons disease, diabetes, and diseases related to oxidative stress resistance[1][2].
Molecular Weight:
256.68
CAS Number:
[27052-20-6]
Formula:
C15H9ClO2
Target:
Amylases,Monoamine Oxidase
Application Notes:
MCE Product type: Reference compound
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