N-Isonicotinoylisonicotinohydrazide (Compound 7, 1,2-Diisonicotinoylhydrazine) is a competitive inhibitor (IC50=5-30 µM) of bacterial heme oxygenase (HO). N-Isonicotinoylisonicotinohydrazide inhibits iron release and bacterial iron acquisition. N-Isonicotinoylisonicotinohydrazide exhibits selective activity against HO enzymes from Pseudomonas aeruginosa and Neisseria meningitidis. N-Isonicotinoylisonicotinohydrazide is promising for research of multidrug-resistant Gram-negative bacterial infections[1][2].
Molecular Weight:
242.23
Purity:
99.55
CAS Number:
[4329-75-3]
Formula:
C12H10N4O2
Target:
Bacterial,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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