Viloxazine is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC50= 0.26 µM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (Ki=4.2 µM) and agonizes 5-HT2C receptors (EC50= 32 µM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD)[1][2][3].
Molecular Weight:
237.29
CAS Number:
[46817-91-8]
Formula:
C13H19NO3
Target:
5-HT Receptor
Application Notes:
MCE Product type: Reference Standards
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