Thalidomide-1-Me,4-OH is a Thalidomide (HY-14658) analogue. Thalidomide-1-Me,4-OH contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.
Molecular Weight:
288.26
Purity:
98
CAS Number:
[2244568-06-5]
Formula:
C14H12N2O5
Target:
Ligands for E3 Ligase
Application Notes:
MCE Product type: Reference compound
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