1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE, 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines[1][2].
Molecular Weight:
718.00
Purity:
99.46
CAS Number:
[26662-94-2]
Formula:
C39H76NO8P
Target:
Liposome
Application Notes:
MCE Product type: Oligonucleotides
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