Glycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 47.9 and 66.8 µM (absence of Zn2+) and 8 and 8.7 µM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease[1][2][3].
Molecular Weight:
557.65
Purity:
99.73
CAS Number:
[64936-82-9]
Formula:
C26H41NNa2O7S
Target:
GPR39,HIV
Application Notes:
MCE Product type: Reference compound
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