4 -DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 -DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 -DTMP has potential inhibition of E.coli[1].
Molecular Weight:
276.30
Purity:
97.85
CAS Number:
[21253-58-7]
Formula:
C13H16N4O3
Target:
Dihydrofolate reductase (DHFR)
Application Notes:
MCE Product type: Reference compound1
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