ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002 (HY-175283). ABS-752 has the potential for the research of hepatocellular carcinoma[1].
Molecular Weight:
291.28
CAS Number:
[2761170-84-5]
Formula:
C14H14FN3O3
Target:
Molecular Glues,NEKs
Application Notes:
MCE Product type: Reference compound1
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