FP802 hydrochloride is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 hydrochloride exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimers disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-beta plaque formation, and mitigating mitochondrial pathology[1]. FP802 hydrochloride stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS)[2]. FP802 hydrochloride can be used for AD and ALS research[1][2].
Molecular Weight:
285.64
Purity:
99.84
CAS Number:
[2490401-57-3]
Formula:
C11H19Cl3N2
Target:
iGluR,TRP Channel
Application Notes:
MCE Product type: Reference compound1
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