Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.
Molecular Weight:
597.66
Purity:
97
CAS Number:
[899452-51-8]
Formula:
C29H27NO9S2
Target:
Biochemical Assay Reagents
Application Notes:
MCE Product type: Reference compound
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