D-alpha-Hydroxyglutaric acid-d5 (disodium)

Product Overview

• Article Name: D-alpha-Hydroxyglutaric acid-d5 (disodium)
• Biozol Catalog Number: MCE-HY-W654003
• Supplier Catalog Number: HY-W654003
• Alternative Catalog Number: MCE-HY-W654003-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: Disodium (R)-2-hydroxyglutarate-d5

Product Description

D-alpha-Hydroxyglutaric acid-d5 disodium (Disodium (R)-2-hydroxyglutarate-d5) is the deuterium labeled D-alpha-Hydroxyglutaric acid disodium (HY-100542). D-alpha-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-alpha-Hydroxyglutaric acid disodium is a weak competitive antagonist of alpha-ketoglutarate (alpha-KG) and inhibits multiple alpha-KG-dependent dioxygenases with a Ki of 10.87 mM. D-alpha-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-alpha-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].

Product Properties

• Molecular Weight: 197.11
• Purity: 98.14
• Formula: C5HD5Na2O5
• Target: Reactive Oxygen Species (ROS)

Application Notes

• Application Notes: MCE Product type: Reference compound