GSK-3beta/G9a-IN-1, CAS [[154866-92-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-W657887
Supplier Catalog Number:
HY-W657887
Alternative Catalog Number:
MCE-HY-W657887-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
GSK-3beta/G9a-IN-1 (Compound T2) is an orally active, selective, blood-brain-barrier permeable, competitive G9a (substrate-competitive, IC50: 1.1 µM) and GSK-3beta (ATP competitive, IC50: 0.8 µM) inhibitor. GSK-3beta/G9a-IN-1 is a potent H3K9me2 inhibitor that reshapes chromatin landscape. GSK-3beta/G9a-IN-1 lowers tau phosphorylation, reduces Abeta aggregation. GSK-3beta/G9a-IN-1 displays inhibition toward glucocorticoid receptor, androgen receptor, and alpha-2A adrenergic receptor. GSK-3beta/G9a-IN-1 also upregulates SAGA complex members such as Eny2 and Sgf29. GSK-3beta/G9a-IN-1 markedly improves memory, restores social behaviors, and increases synaptic complexity in late-onset Alzheimers disease[1].
Molecular Weight:
310.80
CAS Number:
[154866-92-9]
Formula:
C14H15ClN2O2S
Target:
Adrenergic Receptor,Amyloid-beta,Androgen Receptor,Glucocorticoid Receptor,GSK-3,Histone Methyltransferase,Tau Protein
Application Notes:
MCE Product type: Reference compound
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