ABI-274 is a tubulin and colchicine binding site inhibitor. ABI-274 significantly promotes cancer cell apoptosis in vitro when combined with vemurafenib (HY-12057). ABI-274 exhibits potent synergistic efficacy in the vemurafenib-resistant xenograft model in nude mice. ABI-274 can be studied in research on melanoma[1].
Molecular Weight:
352.38
CAS Number:
[1253697-93-6]
Formula:
C20H20N2O4
Target:
Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound1
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